Cruise Act bill that, if passed, would revoke the agency’s Conditional Sail Order and require it to issue new guidance to restart United States sailings. (Because of a quirk of maritime law, several major cruise lines have canceled all 2021 sailings to Alaska.)

“With the way this is going, it seems that the C.D.C. doesn’t want the cruise industry to be in business because they are not setting the rules in a manner that the cruise industry feels they can comply and safely return to work,” Senator Scott said in a telephone interview.

“Cruise lines clearly want their passengers and employees to be safe,” he continued. “They have been working all year to prepare their ships, but the C.D.C. has been very difficult to work with and if they don’t want to help then we’ll make sure they do it because we are going to pass this legislation.”

sued the federal government to demand cruise ships be allowed to start sailing immediately.

Gov. Ron DeSantis, also a Republican, has maintained that the cruise ban has had a disproportionate impact on the state’s economy; cruises usually generates billions of dollars from the millions of passengers that pass through Florida’s ports each year.

“People are going to cruise one way or another. The question is are we going to do it out of Florida, which is the number one place to do it in the world, or are they going to be doing it out of the Bahamas or other locations?” Gov. DeSantis said, speaking at a recent news conference at PortMiami.

Ms. Sell said she thinks the C.D.C.’s phased approach, where safety protocols are tested out before passengers are allowed back on onboard, is the right one.

“Cruises have for a long time had a potential to super spread diseases that include Covid because people are often in close quarters,” she said. “I’m not saying that you could never do cruises again, but that it just needs to be something where you sort through all the requirements.”

MSC Cruises, the industry’s fourth-largest operator, announced on Thursday that it would be canceling all U.S. cruises through June 30 and instead plans to have at least 10 ships sailing out of Europe and the Mediterranean by August. Royal Caribbean, the second-largest by passenger count, is sailing out of the Bahamas and Bermuda, among other places, and is requiring vaccinations for all crew and passengers.

Before vaccines were being widely distributed, cruises lines operating in Europe reported some Covid infections on board, but say that the cases were brought under control using stringent health and safety protocols, which prevented any larger outbreaks.

The C.D.C.’s advisory regarding cruise travel remains at a Level 4, the highest, and the agency recommends that all people avoid travel on cruise ships, including river cruises, worldwide.

That’s because the chance of getting Covid-19 on cruise ships is high since the virus appears to spread more easily between people in close quarters aboard ships,” the warning says.

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