sewn into the linings of clothes.

In May, after Saudi authorities discovered more than five million pills hidden inside hollowed out pomegranates shipped from Beirut, they banned produce from Lebanon, a major blow to local farmers.

According to The Times’ database, the number of pills seized has increased every year since 2017.

The street value of the drugs seized has outstripped the value of Syria’s legal exports, mostly agricultural products, every year since 2019.

Last year, global captagon seizures had a street value of about$2.9 billion, more than triple Syria’s legal exports of $860 million.

Law enforcement agencies have struggled to catch the smugglers, not least because the Syrian authorities offer little if any information about shipments that originated in their country.

The name of shippers listed on manifests are usually fake and searches for the intended recipients often lead to mazes of shell companies.

The Italian seizure of 84 million pills in Salerno last year, the largest captagon bust ever at the time, had come from Latakia. Shipping documents listed the sender as Basil al-Shagri Bin Jamal, but the Italian authorities were unable to find him.

GPS Global Aviation Supplier, a company registered in Lugano, Switzerland, that appears to have no office.

Phone calls, text messages and emails to the company received no response, and the wealth management firm that the company listed as its mailing address, SMC Family Office SA, declined to comment.

Greek investigators have hit similar roadblocks.

In June 2019, workers in Piraeus found five tons of captagon, worth hundreds of millions of dollars, inside sheets of fiberboard on their way to China.

Seehog, a Chinese logistics firm. When reached by phone, she denied knowing anything about the shipment and refused to answer questions.

“You are not the police,” she said, and hung up.

There was one more clue in the documents: The sender was Mohammed Amer al-Dakak, with a Syrian phone number. When entered into WhatsApp, the phone number showed a photo of Maher al-Assad, the commander of Syria’s Fourth Armored Division, suggesting the number belonged to, at least, one of his fans.

A man who answered that number said that he was not Mr. al-Dakak. He said that he had acquired the phone number recently.

Loukas Danabasis, the head of the narcotics unit of Greece’s financial crime squad, said the smugglers’ tactics made solving such cases “difficult and sometimes impossible.”

While officials in Europe struggle to identify smugglers, Jordan, one of the United States’ closest partners in the Middle East, sits on the front lines of a regional drug war.

“Jordan is the gateway to the Gulf,” Brig. Gen. Ahmad al-Sarhan, the commander of an army unit along Jordan’s border with Syria, said during a visit to the area.

Overlooking a deep valley with views of Syria, General al-Sarhan and his men detailed Syrian smugglers’ tricks to bring drugs into Jordan: They launch crossing attempts at multiple spots. They attach drugs to drones and fly them across. They load drugs onto donkeys trained to cross by themselves.

Sometimes the smugglers stop by Syrian army posts before approaching the border.

“There is clear involvement,” General al-Sarhan said.

The drug trade worries Jordanian officials for many reasons.

The quantities are increasing. The number of Captagon pills seized in Jordan this year is nearly double the amount seized in 2020, according to Colonel Alqudah, the head of the narcotics department.

And while Jordan was originally just a pathway to Saudi Arabia, as much as one-fifth of the drugs smuggled in from Syria are now consumed in Jordan, he estimated. The increased supply has lowered the price, making it easy for students to become addicted.

Even more worrying, he said, is the growing quantity of crystal meth entering Jordan from Syria, which poses a greater threat. As of October, Jordan had seized 132 pounds of it this year, up from 44 pounds the year before.

“We are now in a dangerous stage because we can’t go back,” said Dr. Morad al-Ayasrah, a Jordanian psychiatrist who treats drug addicts. “We are going forward and the drugs are increasing.”

Reporting was contributed by Niki Kitsantonis in Athens; Gaia Pianigiani in Rome; Kit Gillet in Bucharest, Romania; Hannah Beech in Bangkok; and employees of The New York Times in Damascus, Syria, and Beirut, Lebanon.

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Drug Overdose Deaths Have Surged During the Pandemic, C.D.C. Says

On Tuesday, several dozen organizations that work on addiction and other health issues asked Mr. Biden’s health and human services secretary, Xavier Becerra, to “act with urgency” and eliminate the rule that doctors go through a day of training before getting federal permission to prescribe buprenorphine. Many addiction experts are also calling for abolishing rules that had already been relaxed during the pandemic so that patients don’t have to come to clinics or doctors’ offices for addiction medications.

Although many programs offering treatment, naloxone and other services for drug users have reopened at least partly as the pandemic has dragged on, many others remain closed or severely curtailed, particularly if they operated on a shoestring budget to begin with.

Sara Glick, an assistant professor of medicine at the University of Washington, said a survey of about 30 syringe exchange programs that she conducted last spring found that many closed temporarily early in the pandemic. After reopening, she said, many programs cut back services or the number of people they could help.

“With health departments spending so much on Covid, some programs have really had to cut their budgets,” she said. “That can mean seeing fewer participants, or pausing their H.I.V. and hepatitis C testing.”

At the same time, increases in H.I.V. cases have been reported in several areas of the country with heavy injection drug use, including two cities in West Virginia, Charleston and Huntington, and Boston. West Virginia’s legislature passed a law last week placing new restrictions on syringe exchange programs, which advocates of the programs said would force many to close.

Mr. Biden’s American Rescue Plan Act includes $1.5 billion for the prevention and treatment of substance use disorders, as well as $30 million in funding for local services that benefit people with addiction, including syringe exchange programs. The latter is significant because while federal funds still largely cannot be spent on syringes for people who use drugs, the restriction does not apply to money from the stimulus package, according to the Office of Drug Control Policy. Last week, the administration announced that federal funding could now be used to buy rapid fentanyl test strips, which can be used to check whether drugs have been mixed or cut with fentanyl.

Fentanyl or its analogues have increasingly been detected in counterfeit pills being sold illegally as prescription opioids or benzodiazepines — sedatives like Xanax that are used as anti-anxiety medications — and particularly in meth.

Northeastern states that had been hit hardest by opioid deaths in recent years saw some of the smallest increases in deaths in the first half of the pandemic year, with the exception of Maine. The hardest-hit states included West Virginia and Kentucky, which have long ranked at the top in overdose deaths, but also western states like California and Arizona and southern ones like Louisiana, South Carolina and Tennessee.

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